Browsing by Author "Herrera Videla, Emilio Augusto"

Now showing items 1-11 of 11

    • Biomechanical and structural responses of the aorta to intermittent hypobaric hypoxia in a rat model 
      Utrera, Andrés; Navarrete, Álvaro; González Candia, Alejandro Antonio; García Herrera, Claudio Moisés; Herrera Videla, Emilio Augusto (Nature, 2022)
      High altitude hypoxia is a condition experienced by diverse populations worldwide. In addition, several jobs require working shifts where workers are exposed to repetitive cycles of hypobaric hypoxia and normobaric ...
    • Biomechanical characterization of the passive response of the thoracic aorta in chronic hypoxic newborn ... 
      Rivera, Eugenio; Canales, Claudio; Pacheco, Matías; García Herrera, Claudio; Macías, Demetrio; Celentano, Diego J.; Herrera Videla, Emilio Augusto (Nature, 2021)
      The present study involves experiments and modelling aimed at characterizing the passive structural mechanical behavior of the chronic hypoxic lamb thoracic aorta, whose gestation, birth and postnatal period were carried ...
    • Cardioprotective antioxidant and anti-inflammatory mechanisms induced by intermittent hypobaric hypoxia 
      González Candia, Alejandro; Candia Henríquez, Alejandro Andrés; Paz, Adolfo; Mobarec Lubies, Fuad Cristóbal Rachid; Urbina Varela, Rodrigo; Campo, Andrea del; Herrera Videla, Emilio Augusto; Castillo Peñaloza, Rodrigo Luis (MDPI, 2022)
      More than 80 million people live and work (in a chronic or intermittent form) above 2500 masl, and 35 million live in the Andean Mountains. Furthermore, in Chile, it is estimated that 100,000 people work in high-altitude ...
    • Cinaciguat (BAY-582667) modifies cardiopulmonary and systemic circulation in chronically hypoxic and pulmonary ... 
      Beñaldo Fuentes, Felipe Augusto; Araya Quijada, Claudio Enrique; Ebensperger Darrouy, Germán; Herrera Videla, Emilio Augusto; Reyes, Roberto V.; Moraga, Fernando A.; Riquelme Herrera, Alexander Nathan; González Candia, Alejandro; Castillo Galán, Sebastián; Valenzuela, Guillermo J.; Serón Ferré, María Josefa; Llanos, Aníbal J. (Frontiers Media, 2022)
      Neonatal pulmonary hypertension (NPHT) is produced by sustained pulmonary vasoconstriction and increased vascular remodeling. Soluble guanylyl cyclase (sGC) participates in signaling pathways that induce vascular vasodilation ...
    • Gestational hypoxia and blood-brain barrier permeability: early origins of cerebrovascular dysfunction ... 
      Herrera Videla, Emilio Augusto; González Candia, Manuel Alejandro (Frontiers Media, 2021)
      Fetal chronic hypoxia leads to intrauterine growth restriction (IUGR), which is likely to reduce oxygen delivery to the brain and induce long-term neurological impairments. These indicate a modulatory role for oxygen in ...
    • High altitude pregnancies and vascular dysfunction: observations From Latin American studies 
      González Candia, Alejandro Antonio; Herrera Videla, Emilio Augusto (Frontiers Media, 2021)
      An estimated human population of 170 million inhabit at high-altitude (HA, above 2,500 m). The potential pathological effects of HA hypobaric hypoxia during gestation have been the focus of several researchers around the ...
    • Identificación de posibles vías de intervención farmacológica para prevenir los efectos de gestaciones ... 
      Candia Henríquez, Alejandro Andrés (Universidad de Chile, 2022)
      Adecuados niveles de oxígeno y nutrientes son fundamentales para el correcto desarrollo de la gestación. Alteraciones en estos factores, como, por ejemplo, una disminución del oxígeno ambiental y/o una malnutrición materna ...
    • Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction ... 
      Hansell, Jeremy A.; Richter, Hans G.; Camm, Emily J.; Herrera Videla, Emilio Augusto; Blanco, Carlos E.; Villamor, Eduardo; Patey, Olga V.; Lock, Mitchell C.; Trafford, Andrew W.; Galli, Gina L. J.; Giussani, Dino A. (Wiley, 2021)
      Adopting an integrative approach, by combining studies of cardiovascular function with those at cellular and molecular levels, this study investigated whether maternal treatment with melatonin protects against programmed ...
    • Melatonin reduces oxidative stress in the right ventricle of newborn sheep gestated under chronic hypoxia 
      González Candia, Alejandro Antonio; Arias, Pamela V.; Aguilar, Simón A.; Figueroa, Esteban G.; Reyes, Roberto V.; Ebensperger Darrouy, Germán; Llanos, Aníbal J.; Herrera Videla, Emilio Augusto (MDPI, 2021)
      Pulmonary arterial hypertension of newborns (PAHN) constitutes a critical condition involving both severe cardiac remodeling and right ventricle dysfunction. One main cause of this condition is perinatal hypoxia and oxidative ...
    • Molecular regulation of lung maturation in near-term fetal sheep by maternal daily vitamin C treatment in ... 
      McGillick, Erin; Orgeig, Sandra; Allison, Beth J.; Brain, Kirsty L.; Niu, Youguo; Itani, Nozomi; Skeffington, Katie; Kane, Andrew; Herrera Videla, Emilio Augusto; Morrison, Janna L.; Giussani, Dino A. (Springernature, 2021)
      BACKGROUND: In the fetus, the appropriate balance of prooxidants and antioxidants is essential to negate the detrimental effects of oxidative stress on lung maturation. Antioxidants improve respiratory function in postnatal ...
    • The Action of 2-aminoethyldiphenyl borinate on the pulmonary arterial hypertension and remodeling of ... 
      Castillo Galán, Sebastián; Parrau Vargas, Daniela Beatriz Angela; Hernández Álvarez, Ismael Charles; Quezada, Sebastián; Díaz Navarrete, Marcela; Ebensperger Darrouy, Germán; Herrera Videla, Emilio Augusto; Moraga, Fernando A.; Iturriaga, Rodrigo; Llanos Mansilla, Jorge Aníbal; Reyes Catalán, Víctor Roberto (Frontiers Media, 2022)
      Calcium signaling is key for the contraction, differentiation, and proliferation of pulmonary arterial smooth muscle cells. Furthermore, calcium influx through store-operated channels (SOCs) is particularly important in ...